The loss of cellular vitality is caused by a number of factors, including mitochondrial problems, glycation, and free radical reactions. Life Extension® members have access to a state-of-the art nutritional formula called Mitochondrial Energy Optimizer that helps protect delicate cellular structures and enables cells to perform life-sustaining metabolic processes. Mitochondrial Energy Optimizer is designed to counteract age-related structural and functional changes by providing the following unique ingredients:
• Carnosine As humans age, proteins in their bodies become irreversibly damaged by glycation reactions. Glycation is the cross-linking of proteins and sugar to form nonfunctioning structures (advanced glycation end-products or AGEs) in the body, which can lead to alterations of normal cell function. Carnosine is not only a powerful antiglycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.
• Luteolin Systemic inflammation is involved in most undesirable consequences of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to modulate these dangerous inflammatory cytokines.
• Benfotiamine Effectively modulates multiple destructive biochemical pathways, including AGEs’ formation pathway, which are induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.12-14 Benfotiamine protects endothelial cell integrity from the effects of high glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.
• Pyridoxal 5’-phosphate Aging is associated with the formation of advanced glycation endproducts throughout the body. Pyridoxal 5’-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.
• R-lipoic acid Destructive free-radical activity in the mitochondria plays a major role in the loss of cellular vitality. A new microencapsulated Bio-Enhanced® R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.
• Acetyl-L-carnitine arginate The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. Acetyl-L-carnitine arginate is a patented form of carnitine that also supports neurites in the brain.